About Cord Lining Epithelial Stem Cells (CLEpSCs)
CLEpSCs are pluripotent, which means they can turn into many different types of epithelial cells. CLEpSCs are considered a key resource for epidermal and skin regeneration as they have demonstrated their potential in the treatment of skin wounds, ocular surface disorders, and eyes with persistent corneal epithelial defect.
EC, EpSC or CLEpSC Clinical Trials – Global Institutions
|Diseases||Names of Universities or Research Institutions|
|Skin wound||Singapore General Hospital Burn Centre|
|Ocular surface disorders||Singapore Eye Research Centre|
Kyoto Prefectural University of Medicine, Japan
|La Trobe University, Australia|
|Persistent corneal epithelial defect||Vietnam National Institute of Ophthalmology|
EC, EpSC or CLEpSC Application Reports
- The clinical trial was conducted by Singapore General Hospital, Burn Centre.
- Eight patients with 10 skin wounds were treated with autologous and allogenic skin epithelium (keratinocytes) cultured and transplanted with polymer dressing aid.
- Rapid re-epithelialisation, closure and healing of wounds were observed.
Source: Tay AG et al. Cultured subconfluent keratinocytes on wound polymer dressings in the treatment of burns and chronic wounds. Wounds. 2000 12(5):127-133.
- Human amnion epithelial cells have shown to help reduce brain injury and aid recovery in mice in a study led by La Trobe University.
- The success of this pre-clinical study led to an approved Phase 1 human clinical trial in Australia.
- A patient who had a stroke in February 2019 was reported to have made remarkable recovery about a day after receiving treatment.
- The patient had significant speech problems and arm weakness following his stroke, but after the treatment, he only had mild facial droop and no further brain tissue damage.
Source: Evans MA, Lim R, Kim HA, et al. Acute or delayed systemic administration of human amnion epithelial cells improves outcomes in experimental stroke. Stroke. 2018;49:700-709.
Source: Australia’s Science Channel page. La Trobe University. https://australiascience.tv/world-first-stem-cell-therapy-trial-begins-in-melbourne/. Accessed 3 March 2020.
- Human amnion epithelial cells have been shown to prevent acute lung injury, but to see if they can repair existing lung damage, researchers gave the cells to mice with induced lung damage seven or 14 days after the damage was inflicted.
- According to their findings, human amnion epithelial cells delivered 14 days after damage induction were capable of repairing the established lung injury.
Source: Vosdoganes P, Wallace EM, Chan ST, Acharya R, Moss T, Lim R. Human amnion epithelial cells repair established lung injury. Cell Transplant. 2013;22:1337-49.
Persistent corneal epithelial defect
- 37 patients with persistent corneal epithelial defect (PED) were studied at the Vietnam National Institute of Ophthalmology.
- All of these patients had corneal defects at the period time from 4 to 28 weeks, and the period time of PED was from 2 to 13 weeks.
- 34 of 37 patients were healed (success rate at 91.9%).
- 22 of the patients recovered within a week.
Source: Ngan ND, Chau HM, Dong PN, et al. Tissue-cultured human cord lining epithelial cells in treatment of persistent corneal epithelial defect. Open Access Maced. J. Med. Sci. 2019;7(24):4266-4271.
Ocular surface disorders
- Singapore Eye Research Centre conducted a trial in which seven patients with various ocular surface disorders were treated.
- Autologous harvesting and cultivation of conjunctival epithelial stem cells were used.
- Cultivation of conjunctival epithelial cells on human amniotic membrane was carried out under serum-free conditions.
- All patients recovered completely, with no complications.
Source: Tan DT et al. Reconstruction of the ocular surface by transplantation of a serum-free derived cultivated conjunctival epithelial equivalent. Transplantation. 2004 77(11): 1729-1734.
- Nine patients with severe ocular surface disorders received treatment in a clinical trial conducted by Kyoto Prefectural University of Medicine, Japan.
- Autologous serum (AS) from patients was used to culture corneal epithelial cells on an amniotic membrane substrate.
- Allogeneic or autologous AS-derived cultivated corneal epithelial equivalents were transplanted onto the patients' ocular surface.
- Rapid corneal epithelialisation was achieved with improved visual acuity. Patients' corneas were also stable and transparent.
Source: Nakamura T, et al. Transplantation of autologous serum-derived cultivated corneal epithelial equivalents for the treatment of severe ocular surface disease. Ophthalmology. 2006;113(10):1765-1772.
DCR No. 4218, Version A, May 2021